Friday, March 20, 2009

CVS Drugs

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Ibnu Shaukani on March 20, 2009 at 11:21 PM said...

makan dalam la gg!! =P

Ibnu Shaukani on March 20, 2009 at 11:50 PM said...

dah alang2 gg letak tajuk nih, so, tgn aku gatal plak nak menulis sebab tgh xde mood lgsung nak stdy. so, bersiap sedia utk tajuk diuretics.

1) how many groups of diuretics do we have?
kita ada 6 groups (COLATA):
- Carbonic anhydrase inhibitor
- Osmotic agents
- Loop agents
- Aldosterone antagonists
- Thiazides
- ADH antagonists

2)site of action of the drugs (ni yg best ni!)
- CA inhibitor act dkat proximal tubule
- Osmotic agents act dkat proximal tubule and thin descending limb of loop of henle (LOH)
- loop diuretics -> THICK ascending limb of LOH
- aldosterone antagonists - collecting duct
- thiazides - distal convoluted tubules
- ADH antagonists - collecting duct

3) MOA of drugs :
- CA inhibitor - inhibit CA -> block HCO3 reabsorption -> HCO3 diuresis
- osmotic agents - increased osmolarity lead to retention of water within tubules -> osmotic diuresis
- loop agents - inhibit NaCl reabsorption
- aldosterone antagonists - prevent action of aldosterone at collecting duct (K+ sparing diuretics)
- thiazides - inihibit NaCl reabsorption in distal convoluted tubules
- ADH antagonists - prevent action of ADH at collecting tubules

4) examples of drugs :
- CA inhibitor - acetozolamide
- osmotic agents - xda cnth plak
- loop agents - furosemide
- aldosterone antagonists - spironolactone, amiloride
- thiazides - hydrochlorothiazide, chlorothiazide
- ADH antagonists - conivaptan, demeclocydine

abes lah, tp yg pnting adalah thiazides and loop agents..kalu de silap, btau ye..syukran..=)

Ibnu Abas on March 21, 2009 at 6:58 AM said...

keyakinan azizi!!!!!!!!!!!!

gg on March 21, 2009 at 8:30 AM said...

opss... rajen eh ko menaip... kat ats tuh ade summary ape2 yg ko ckp td... bagus2, thn dpn ganti prof aida bg lecture k... *ops*

ainaa ismail on March 21, 2009 at 1:03 PM said...

if patient is having asthma,jgn bgi Beta blocker.nnti dpt bronchospasm.

and ifpatient hving cough after taking ACEI,replace the drug with ARB

azizi,carbanic anhydrase inhibitor notes mana?awattak pernah dgr?

Anonymous said...

note dr LJH pasal diuretic(GUT BLOCK) ader mention psal tue aina..


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