Acute Postinfectious (post streptococcal) glomerulonephritis
Etiological agents
1. Bacteria -->Streptococcus (group A,B-hemolytic),Staphylococcus
2. viral-->measles,hepatitis B,hepatitis C
Pathogenesis
Following infections to etiologic agents
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formation of immune complex (complement and IgG formed against the insulting agents – in circulation or in-situ)
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stimulate further release of Growth Factors and Interleukin
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stimulate proliferation of glomerular cells (mesangial cell and endothelial cells)
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glomerular cells secrete nephrotoxins (oxidants, protease)
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activation of leukocytes (primarily neutrophils)
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leukocytes infiltration within glomeruli
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capillary walls damage (due to inflammatory insults)
Morphology
- increased cellularity of glomerular cells due to:
- proliferation and swelling of endothelial and mesangial cells
- infiltration of leukocytes (neutrophils & monocytes)
-necrosis of capillary walls
-crescents within urinary space
1 comments:
1) utk pathophysiology bg APSGN ni, just citer pasal hypersensitivity type 3 je.. dah cukup..
2) cresentric shape tu biasanya dah masuk rapidly progressive glomerulonephritis..
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